Despite the strongest objections from every possible authority including district attorney Harvey Dent, Dr. Harleen Quinzel's found herself with free access to every inmate in Arkham Asylum, where she desperately pursues a revolutionary and highly controversial cure to the insanity of Gotham. But her work with the city's super-criminals quickly muddies the waters of good and evil, and in the deepest, darkest padded rooms of Arkham, even the words of a mad clown start making sense!